square Examples of network-based analysis application (2011-2012):

Early G1 cyclin-dependent kinases as prognostic markers and potential therapeutic targets in esophageal adenocarcinoma. Ismail A, Bandla S, Reveiller M, Toia L, Zhou Z, Gooding WE, Kalatskaya I, Stein L, D'Souza M, Litle VR, Peters JH, Pennathur A, Luketich JD, Godfrey TE.: Clin Cancer Res. 2011 Jul 1;17(13):4513-22. PubMed

Alterations in tumor necrosis factor signaling pathways are associated with cytotoxicity and resistance to taxanes: a study in isogenic resistant tumor cells. Sprowl JA, Reed K, Armstrong S, Lanner C, Guo B, Kalatskaya I, Stein L, Hembruff SL, Parissenti AM.: Breast Cancer Res. 2012 Jan 6;14(1):R2. PubMed

Bile Exposure Inhibits Expression of Squamous Differentiation Genes in Human Esophageal Epithelial Cells. Reveiller M, Ghatak S, Toia L, Kalatskaya I, Stein L, D’Souza M, Zhou Z, Bandla S, Gooding WE, Godfrey TE and Peters J:Ann Surg. 2012 Jun;255(6):1113-20.PubMed

* This is not a summary of the paper. This is a description of the network-based analysis application, building a readable story and, if possible, validation.

square Keywords:

Drug target discovery using bioinformatics tools, biomarker identification, Machine Learning, R, Python, Rshiny, Reactome, protein pathways and networks, network biology.

square Contact me:

ikalats at

square Publications:

Perform an automatic PubMed search of my publications

square My motto:

I hope my grandchildren
will think about cancer like
we think now about the Bubonic plague or smallpox.

Last updated: November 2020